drugs

[Blackchocob0]

The Only Drugs Ive Ever Taken Are:

Coffee,
Alcohol,
Chocolate.

The rest, will never and have never touched. Even though some of my friends are druggys

And what makes alcohol acceptable compared to any other?

Psych never done lsd but I hurt my brain from my last trip.

Literally, I had only what I could call mental pain.

Physical pain is better.

[Zypher]

snorted adderall

is the worst ive ever done.

correction* only ive ever done*

[PimpC]

Crack=worst drug just because it kills people so fast.

[XemnasXD]

The Only Drugs Ive Ever Taken Are:

Coffee,
Alcohol,
Chocolate.

The rest, will never and have never touched. Even though some of my friends are druggys

since when was chocolate a drug?
or coffee...i know it has caffiene in it but you know caffiene doesn't really count as a drug imo...its basically harless when used in moderation just like anything else....its like calling sugar adrug cause you can get hyper from it

[Silver0]

The Only Drugs Ive Ever Taken Are:

Coffee,
Alcohol,
Chocolate.

The rest, will never and have never touched. Even though some of my friends are druggys

since when was chocolate a drug?
or coffee...i know it has caffiene in it but you know caffiene doesn't really count as a drug imo...its basically harless when used in moderation just like anything else....its like calling sugar adrug cause you can get hyper from it

there a drug

sugar isnt
but caffeine is

[mosiac]

weed is natural. it can grow naturally without man touching it and it still does what it's suppose to do.. which is why I like it. I don't have any memory problems, nor any problems to tell you the truth. mushrooms are great.. and also natural. hash is nice.
but meth and crack for sure.. I have friends who have been ruined because of those drugs

Natuaral means nothing.
Many drugs are natural.
Nature can produce deadly toxics who can kill you with ease, don't think natural is safe.

Just as much of a junkie as the guy who drinks 5 cups of coffee a day.

Or has a few drinks every day.

QFT

yes nature can make extremely deadly toxins.
But are those toxins are in peyote, mushrooms, marijuana, salvia, I dont really feel like looking up every natural drug, ?

[BlackFox]

The Only Drugs Ive Ever Taken Are:

Coffee,
Alcohol,
Chocolate.

The rest, will never and have never touched. Even though some of my friends are druggys

since when was chocolate a drug?
or coffee...i know it has caffiene in it but you know caffiene doesn't really count as a drug imo...its basically harless when used in moderation just like anything else....its like calling sugar adrug cause you can get hyper from it

Never know Chocolate can be very dangerous for you .. So stay away from it
And to drink Chocolate Can be more dangerous for you

[MasterKojito]

The Only Drugs Ive Ever Taken Are:

Coffee,
Alcohol,
Chocolate.

The rest, will never and have never touched. Even though some of my friends are druggys

since when was chocolate a drug?
or coffee...i know it has caffiene in it but you know caffiene doesn't really count as a drug imo...its basically harless when used in moderation just like anything else....its like calling sugar adrug cause you can get hyper from it

+1

[bambskiii]

heroine and silkroad, both messes your sociallife up totaly and forget about family and friends.

[Stress]

Silkroad, Crack and alcohol are the worst there can be.

EDIT: Dammit, I almost forgot to mention WoW...

[takolin]

weed is natural. it can grow naturally without man touching it and it still does what it's suppose to do.. which is why I like it. I don't have any memory problems, nor any problems to tell you the truth. mushrooms are great.. and also natural. hash is nice.
but meth and crack for sure.. I have friends who have been ruined because of those drugs

Natuaral means nothing.
Many drugs are natural.
Nature can produce deadly toxics who can kill you with ease, don't think natural is safe.

Just as much of a junkie as the guy who drinks 5 cups of coffee a day.

Or has a few drinks every day.

QFT

yes nature can make extremely deadly toxins.
But are those toxins are in peyote, mushrooms, marijuana, salvia, I dont really feel like looking up every natural drug, ?

I'm studying them now.
Bio synthesis of many natural drugs.
I don't like stereo chemistry.
By Friday afternoon I can fake impressiveness with many names.

[mosiac]

you make absolutly no sense. I say I like drugs that are natural.. and you say nature can also make deadly toxins. These deadly toxins don't even exist in the drugs that im talking about .... and now you are saying you're studying toxins?

[XemnasXD]

Coffee is not a drug. Stop calling Coffee a drug its stupid, its the equivilant of FOX News makeing a story about e-mail addiction. Just because Someone decides to label something as whatever they wann't doesn't it so. When i drink soda i am not taking drugs, when i drink tea im nto taking drugs, when i drink coffee im not friggin takin any drugs.

Same goes for chocolate. If you get any pleasure or a sense of calmness from chocolate its all in your head. I hate chocolate unless its frozen. In fact nothing makes me angrier than having to eat non-frozen or slightly warm chocolate. Its not a drug!!!!

[Silver0]

Coffee is not a drug. Stop calling Coffee a drug its stupid, its the equivilant of FOX News makeing a story about e-mail addiction. Just because Someone decides to label something as whatever they wann't doesn't it so. When i drink soda i am not taking drugs, when i drink tea im nto taking drugs, when i drink coffee im not friggin takin any drugs.

dude get this right coffee is not a drug but caffeine is

[XemnasXD]

Coffee is not a drug. Stop calling Coffee a drug its stupid, its the equivilant of FOX News makeing a story about e-mail addiction. Just because Someone decides to label something as whatever they wann't doesn't it so. When i drink soda i am not taking drugs, when i drink tea im nto taking drugs, when i drink coffee im not friggin takin any drugs.

dude get this right coffee is not a drug but caffeine is

If you ingest alot off sugar you get the same results as ingesting caffeine. So why isn't sugar labled as a drug? Drugs are defined as anythign that alters the function of the body so if ingesting sugar can give you the same effects as ingesting coffeee why doesn't the FDA monitor sugar consumption and label it as a drug? Coffee is only labled as adrug because the FDA says so (and yes they do have the power to say what is and what is not a drug in the US). Basically im trying to say there are drugs and there are "drugs" and just because someone tells me a "drug" is a drug isn't a good reason for me to consider it in the same catagory as real drugs.

[Silver0]

Coffee is not a drug. Stop calling Coffee a drug its stupid, its the equivilant of FOX News makeing a story about e-mail addiction. Just because Someone decides to label something as whatever they wann't doesn't it so. When i drink soda i am not taking drugs, when i drink tea im nto taking drugs, when i drink coffee im not friggin takin any drugs.

dude get this right coffee is not a drug but caffeine is

If you ingest alot off sugar you get the same results as ingesting caffeine. So why isn't sugar labled as a drug? Drugs are defined as anythign that alters the function of the body so if ingesting sugar can give you the same effects as ingesting coffeee why doesn't the FDA monitor sugar consumption and label it as a drug? Coffee is only labled as adrug because the FDA says so (and yes they do have the power to say what is and what is not a drug in the US). Basically im trying to say there are drugs and there are "drugs" and just because someone tells me a "drug" is a drug isn't a good reason for me to consider it in the same catagory as real drugs.

no you dont trust me taking alot of sugar is not the same as taking alot of caffeine
but w/e believe what you want

[XemnasXD]

Coffee is not a drug. Stop calling Coffee a drug its stupid, its the equivilant of FOX News makeing a story about e-mail addiction. Just because Someone decides to label something as whatever they wann't doesn't it so. When i drink soda i am not taking drugs, when i drink tea im nto taking drugs, when i drink coffee im not friggin takin any drugs.

dude get this right coffee is not a drug but caffeine is

If you ingest alot off sugar you get the same results as ingesting caffeine. So why isn't sugar labled as a drug? Drugs are defined as anythign that alters the function of the body so if ingesting sugar can give you the same effects as ingesting coffeee why doesn't the FDA monitor sugar consumption and label it as a drug? Coffee is only labled as adrug because the FDA says so (and yes they do have the power to say what is and what is not a drug in the US). Basically im trying to say there are drugs and there are "drugs" and just because someone tells me a "drug" is a drug isn't a good reason for me to consider it in the same catagory as real drugs.

no you dont trust me taking alot of sugar is not the same as taking alot of caffeine
but w/e believe what you want

yeah i said ingesting alot of sugar is the same as ingesting caffeine...by that statement i left it up to the reader to deduce that the amount of sugar i was refering too was greater than the amount off caffiene i was refering too. Clearly you in all of your opiniated wisdom over looked that. My mistake next time i'll spell it out.

Im well aware of the effects of too much caffiene vs the effects of to much sugar. My point is that caffeine is labled a drug because of the fast that it has an effect that alters normal human functions....sugar can have the same effects and is still not considered a drug. It is my belief (as i already stated and which you so graciously allowed me permission to use) that caffeine is not harmful in moderation and in moderation its effects are no more dangerous than consuming slightly excessive amounts of sugar and because of that people should not loop it in the same catagory as other real drugs like crack, weed, and heroine

[mosiac]

that caffeine is not harmful in moderation and in moderation its effects are no more dangerous than consuming slightly excessive amounts of sugar and because of that people should not loop it in the same catagory as other real drugs like crack, weed, and heroine

you have to compare the same size of dose from caffeine and sugar.
for instance.. a tablespoon vs a table spoon of sugar. Caffine is much more powerful than sugar at the same amounts, which is why it's labled a drug.

[takolin]

1) Caffeine is a part of the Xanthines.

With Caffeine, Theobromine and Theophyline as 3 resembling molecules.
The only difference is the amount and relative place of the Methylgroups on the molecule.


Caffeinelkjgdlkgzae'tzaefmhmljdhftheobromine jgsqdlifmhezatzzer Theophylline.

They have diuretic effects (Theophylline > theobromine > caffeine)
They also have a positive inotrope effect, meaning they'll increase the force of a heartbeat. They also increase heartbeat and dilates the coronaric arteries. They also have central effects, and trigger brochodilatation.

Increase of physic activity: (caffeine > theophylline >>> theobromine)

Main uses.
Caffeine: psychotonic (sp?)
Theophylline: coronaric dilator, diuretic
Theobromine:


I got that from my course called pharmaceutical chem.
It might not be really clear, because translation wasn't that easy, but I can assure caffeine is a drug.

Sugar isn't one. Increased sugar levels could make one active, but that's because it's metabolized into ATP, the main energy source in your body. and off course it triggers the release of certain hormones, because your body wants the amount off sugar in ones blood at a certain level, but that doesn't make it a drug.

you make absolutly no sense. I say I like drugs that are natural.. and you say nature can also make deadly toxins. These deadly toxins don't even exist in the drugs that im talking about .... and now you are saying you're studying toxins?

I was referring to the fact that natural things aren't necessarily safer as synthetic drugs. Something people tend to forget. And you can't say that things like cocaine are that healthy.
My next exam is phytochemistry and it's about the biosynthesesis of natural drugs in plants, toxicology is for my 4th or 5th year.

[XemnasXD]

1) Caffeine is a part of the Xanthines.

With Caffeine, Theobromine and Theophyline as 3 resembling molecules.
The only difference is the amount and relative place of the Methylgroups on the molecule.


Caffeinelkjgdlkgzae'tzaefmhmljdhftheobromine jgsqdlifmhezatzzer Theophylline.

They have diuretic effects (Theophylline > theobromine > caffeine)
They also have a positive inotrope effect, meaning they'll increase the force of a heartbeat. They also increase heartbeat and dilates the coronaric arteries. They also have central effects, and trigger brochodilatation.

Increase of physic activity: (caffeine > theophylline >>> theobromine)

Main uses.
Caffeine: psychotonic (sp?)
Theophylline: coronaric dilator, diuretic
Theobromine:


I got that from my course called pharmaceutical chem.
It might not be really clear, because translation wasn't that easy, but I can assure caffeine is a drug.

Sugar isn't one. Increased sugar levels could make one active, but that's because it's metabolized into ATP, the main energy source in your body. and off course it triggers the release of certain hormones, because your body wants the amount off sugar in ones blood at a certain level, but that doesn't make it a drug.

The definition of a druh is something that alters the normal functions of an organism. to much sugar can easily alter the human bodies normal functions so why isn'tit considered a drug. I don't need information thorwn at me froma text book because i can pretty tell already its going to agree with my opinion. What would've been a better argument is if you listed all the things that sugar can do that coffee can't and vice versa.

[takolin]

By the broad definition of drugs, one can say that food is a drug, yet it's widely accepted by the whole population, besides you apparently, that food is left out.

I'll edit the post this evening, why I'm near my course of physiology for a nice explanation what happens when your blood level of sugar rises or drops.

This I know by heart.
Sugar is metabolised into carbon dioxide and water and it result in an energy-release. 1 sugar molecule leads to the formation of 36 ATP molecules in the best case.

ATP is hydrolyzed which leads to energy release.
IIRC ATP +H2O <=> ADP + Pi + 31KJ.

Energy = activity
^the basic explanation why one becomes active by eating sugar.

Caffeine acts through multiple mechanisms involving both action on receptors and channels on the cell membrane, as well as intracellular action on calcium and cAMP pathways. By virtue of its purine structure it can act on some of the same targets as adenosine related nucleosides and nucleotides, like the cell surface P1 GPCRs for adenosine, as well as the intracellular Ryanodine receptor which is the physiological target of cADPR (cyclic ADP ribose), and cAMP-phosphodiesterase (cAMP-PDE). Although the action is agonistic in some cases, it is antagonistic in others. Physiologically, however, caffeine action is unlikely due to increased RyR opening, as it requires plasma concentration above lethal dosage. The action is most likely through adenosine receptors.

Like alcohol, nicotine, and antidepressants, caffeine readily crosses the blood brain barrier. Once in the brain, the principal mode of action of caffeine is as an antagonist of adenosine receptors found in the brain.[31] The caffeine molecule is structurally similar to adenosine, and binds to adenosine receptors on the surface of cells without activating them (an "antagonist" mechanism of action). Therefore, caffeine acts as a competitive inhibitor. The reduction in adenosine activity results in increased activity of the neurotransmitter dopamine, largely accounting for the stimulatory effects of caffeine. Caffeine can also increase levels of epinephrine/adrenaline,[32] possibly via a different mechanism. Acute usage of caffeine also increases levels of serotonin, causing positive changes in mood.

The inhibition of adenosine may be relevant in its diuretic properties. Because adenosine is known to constrict preferentially the afferent arterioles of the glomerulus, its inhibition may cause vasodilation, with an increase in renal blood flow (RBF) and glomerular filtration rate (GFR). This effect, called competitive inhibition, interrupts a pathway that normally serves to regulate nerve conduction by suppressing post-synaptic potentials. The result is an increase in the levels of epinephrine and norepinephrine/noradrenaline released via the hypothalamic-pituitary-adrenal axis.[33] Epinephrine, the natural endocrine response to a perceived threat, stimulates the sympathetic nervous system, leading to an increased heart rate, blood pressure and blood flow to muscles, a decreased blood flow to the skin and inner organs. Biochemically, it stimulates glycogenolysis, inhibits glycolysis, and stimulates gluconeogenesis to produce more glucose in the muscles and release of glucose into the blood stream from the liver.

Caffeine is also a known competitive inhibitor of the enzyme cAMP-phosphodiesterase (cAMP-PDE), which converts cyclic AMP (cAMP) in cells to its noncyclic form, allowing cAMP to build up in cells. Cyclic AMP participates in activation of Protein Kinase A (PKA) to begin the phosphorylation of specific enzymes used in glucose synthesis. By blocking its removal caffeine intensifies and prolongs the effects of epinephrine and epinephrine-like drugs such as amphetamine, methamphetamine, or methylphenidate. Increased concentrations of cAMP in parietal cells causes an increased activation of protein kinase A (PKA) which in turn increases activation of H+/K+ ATPase, resulting finally in increased gastric acid secretion by the cell.

Caffeine (and theophylline) can freely diffuse into cells and causes intracellular calcium release (independent of extracellular calcium) from the calcium stores in the Endoplasmic Reticulum(ER). This release is only partially blocked by Ryanodine receptor blockade with ryanodine, dantrolene, ruthenium red, and procaine (thus may involve ryanodine receptor and probably some additional calcium channels), but completely abolished after calcium depletion of ER by SERCA inhibitors like Thapsigargin (TG) or cyclopiazonic acid (CPA).[34] The action of caffeine on the ryanodine receptor may depend on both cytosolic and the luminal ER concentrations of Ca2+. At low millimolar concentration of caffeine, the RyR channel open probability (Po) is significantly increased mostly due to a shortening of the lifetime of the closed state. At concentrations >5 mM, caffeine opens RyRs even at picomolar cytosolic Ca2+ and dramatically increases the open time of the channel so that the calcium release is stronger than even an action potential can generate. This mode of action of caffeine is probably due to mimicking the action of the physiologic metabolite of NAD called cADPR (cyclic ADP ribose) which has a similar potentiating action on Ryanodine receptors.

Caffeine may also directly inhibit delayed rectifier and A-type K+ currents and activate plasmalemmal Ca2+ influx in certain vertebrate and invertebrate neurons.

The metabolites of caffeine contribute to caffeine's effects. Theobromine is a vasodilator that increases the amount of oxygen and nutrient flow to the brain and muscles. Theophylline, the second of the three primary metabolites, acts as a smooth muscle relaxant that chiefly affects bronchioles and acts as a chronotrope and inotrope that increases heart rate and efficiency. The third metabolic derivative, paraxanthine, is responsible for an increase in the lipolysis process, which releases glycerol and fatty acids into the blood to be used as a source of fuel by the muscles.[35]

Small synopsis.
It increases the dopamine, adrenaline and serotonin release.
> increased hearth rate, blood pressure,....
And stimulates sugar release.

Thus as a conclusion: caffeine does more as sugar.

[Waisha]

omg, drop the caffeine thing lol.

maybe it's a drug but it's almost harmless.

[takolin]

omg, drop the caffeine thing lol.

maybe it's a drug but it's almost harmless.

Drop the maybe and I'll agree with you.

[Waisha]

omg, drop the caffeine thing lol.

maybe it's a drug but it's almost harmless.

Drop the maybe and I'll agree with you.

/drop maybe

I tried to get both of you satisfied. ^^

[PsYch008]

omg, drop the caffeine thing lol.

maybe it's a drug but it's almost harmless.

Drop the maybe and I'll agree with you.

/drop maybe

I tried to get both of you satisfied. ^^

caffeine is NOT almost harmless, if i take too much of it, i get very very sick... i hate caffeine actually.

[Waisha]

Oh shit. Now I'm in the caffeine-argue. ^^

[takolin]

Oh shit. Now I'm in the caffeine-argue. ^^

Welcome to the thread.
I love caffeine.

[Stress]

Scrap the caffeine. It makes ur blood pressure high.-> really unhealthy.

[takolin]

Scrap the caffeine. It makes ur blood pressure high.-> really unhealthy.

My body hates me already.
Smoking is worse as 2 cups of coffee.

[BlackFox]

Scrap the caffeine. It makes ur blood pressure high.-> really unhealthy.

My body hates me already.
Smoking is worse as 2 cups of coffee.

Yea it is true

Oh shit. Now I'm in the caffeine-argue. ^^

Imao ...

I hate coffee..